She will conduct a study of genetic alterations in childhood cancers in sub-Saharan Africa, detected by next generation sequencing. The number of cancer cases increases significantly every year in Africa, though overall case numbers still remain underestimated. The past 30 years have seen the incidence of cancer double, which includes children. The incidence of childhood cancer is said to be the same in developed and developing countries; but the number of recoveries in developed countries is around 80%, while in Africa, the number of deaths is estimated at almost 80%. Genetic predisposition is a major factor in childhood cancers. Understanding the genomic landscape of childhood cancers in developed countries has enabled significant advances in diagnosis, characterization, and treatment of different types of cancer, but no such study has been performed in sub-Saharan Africa. This study will use next generation sequencing to look for genetic abnormalities in children with cancer at several locations across Senegal, to better understand the genetics of cancer tumors as well as genetic alterations most frequently found in patients with each type of cancer, and to determine genetic factors that affect prognosis of the disease, as well as factors of resistance to treatment. This understanding would be a significant contribution to the health and wellbeing of young cancer patients, leading to a better quality of life, a reduction in mortality, and evidence that can prompt health authorities to devote greater attention to cancer.